Associations of Mode of Locomotion and Independence in Locomotion With Long-Term Outcomes After Spinal Cord Injury

Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

Introduction: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). Methods: MEDLINE, Embase, Scopus, and Web of Sciences databases were searched until the end of 2019. Two independent reviewe...

Towards a Spinal Neuroprosthesis: Restoring Locomotion after Spinal Cord Injury

The overall goal of this work is to develop the core framework for an implantable neuroprosthetic device that can restore locomotion after a severe spinal cord injury (SCI) causes paralysis. Our approach to this problem relies on a combination of the biological central pattern generator (CPG) for locomotion and an artificial silicon CPG. In particular, we propose that an artificial CPG can be u...

Restoring voluntary control of locomotion after paralyzing spinal cord injury.

Half of human spinal cord injuries lead to chronic paralysis. Here, we introduce an electrochemical neuroprosthesis and a robotic postural interface designed to encourage supraspinally mediated movements in rats with paralyzing lesions. Despite the interruption of direct supraspinal pathways, the cortex regained the capacity to transform contextual information into task-specific commands to exe...

Locomotion and Motor Neuron Plasticity after Incomplete Spinal Cord Injury

Powered exoskeletons for bipedal locomotion after spinal cord injury.

OBJECTIVE Powered exoskeletons promise to increase the quality of life of people with lower-body paralysis or weakened legs by assisting or restoring legged mobility while providing health benefits across multiple physiological systems. Here, a systematic review of the literature on powered exoskeletons addressed critical questions: What is the current evidence of clinical efficacy for lower-li...